CJC-1295 and Growth Hormone Release

As a derivative of GHRH, it should come as no surprise that CJC-1295 promotes the release of GH. Studies show that a single dose of CJC-1295 increase GH levels in mice by 2-10 times. Peak GH levels are reached approximately 2 hours after administration, and the effects last for about six days. Unlike other GH secretagogues, CJC-1295 preserves normal physiologic release of GH[1]. That means that the normal circadian peaks and valleys seen in GH release remain intact and that CJC-1295 is a physiologic growth hormone releasing factor. Preserving physiologic release of GH even while influencing the maximum concentration of the hormone in the bloodstream is critical to ensuring enhanced effects without increased side effects. In particular, CJC-1295 has been demonstrated to preserve growth hormone’s physiologic effects on hyperplasia, hypertrophy, bone density, blood sugar, fat metabolism, protein synthesis, and myocardial (heart cell) function.

CJC-1295 and Growth

Studies in mice without normal GHRH physiology have shown that CJC-1295 preserves normal GH release[2]. This makes the peptide potentially useful as a therapy for abnormal growth in a variety of mammalian species, humans included. Preserving normal pulsatile release of GH is critical to ensuring that proper release of downstream hormones, such as insulin-life growth factor2 (IGF-1).

CJC-1295 and Infertility

Research from the early 1990s suggests that CJC-1295 and other GRF analogues may be useful in promoting ovulation in infertile female patients. Scientists have long known that ovulation is dependent on IGF-1 and that it is also likely influenced by GH release and cycling. Research in animal models of superovulation has helped to confirm these theories by showing that both GH and IGF-1 levels rise significantly surrounding the time of ovulation. Further, these studies indicate that exogenous administration of GH secretagogues, like CJC-1295, is enough to cause appropriate ovulation[3]. There is some speculation that CJC-1295 and other analogues may even be useful in male infertility by helping to regulate sperm production. This latter hypothesis has yet to be tested.

CJC-1295 Summary

CJC-1295 is a growth hormone secretagogue designed to have a long plasma half-life and to preserve the physiologic patterns inherent in the GH axis. On both accounts, the molecule has been a success. CJC-1295 has experienced limited interest in research settings due to the advent of a number of similar molecules and because of the proprietary nature of the molecule’s structure. Now that CJC-1295 can be manufactured at will, there is likely to be renewed interest in its properties, particularly as they apply to the increasingly frustrating problem of human infertility. CJC-1295 exhibits moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. CJC-1295 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption.

WHAT IS CJC-1295?

CJC-1295 is an incredibly effective peptide which works by stimulating the release of your own body’s growth hormones (which drop quickly after the age of 30). Research has shown that CJC-1295 can increase growth hormone levels by 200-1000% and the elevated growth hormone production continued for up to 6 days.

WHAT IS IPAMORELIN?

Ipamorelin acts in a completely different way than CJC-1295 by mimicking ghrelin. This is an important distinction between both peptides because Ghrelin is responsible for initiating the breakdown of fat for use as energy as well as preventing the breakdown of muscles. Ipamorelin is cleared from the body more rapidly as its half-life is only about 2 hours.

WHY COMBINE CJC-1295 AND IPAMORELIN?

CJC-1295 and Ipamorelin are combined in therapy because they are known to work very well together. Generally, when combined, we see a 3-5 fold increase in growth hormone release over ipamorelin alone. This will increase the benefits of your peptide therapy over using a single peptide alone.

WHEN CAN I EXPECT TO SEE RESULTS?

While patients will notice some significant changes in the body after the first month, the full benefits are usually fully noticed after three to six months of therapy.

Month 1

• Increased energy
• Improved stamina
• Deeper, more restful sleep

Month 2

• Improved skin 
• Reduced wrinkles
• Stronger nails and hair
• Increased metabolism

Month 3

• Enhanced sex drive and performance
• Improved mental focus
• Improved joint health

Month 4

• Continued weight reduction
• Improved skin elasticity
• Increased lean muscle mass

Month 5

• Noticeably fuller, healthier hair
• Reduced appearance of wrinkles 
• Better skin tone
• Continued reduction in belly fat

Month 6

• 5-10% reduction in body fat (without exercise/diet)
• 10% increase in lean muscle mass
• Improved vitality due to organ regrowth

The combination of CJC 1295 and Ipamorelin has been developed because the two can act together on the pituitary and hypothalamus to increase levels of growth hormone in your body. It is done in this way to maximize the amount of growth hormone being released into your body for therapeutic benefit while acting on two separate families of receptors.

The increased volume of human growth hormone (hGH) produced by the pituitary gland have shown to cause an increase in the production of Insulin-Like Growth Factor-1 (IGF-1) by the liver and results in several health benefits such

This combination is used as a subcutaneous injection as prescribed which helps with the following

• Energy and well-being
• Improved bone mineral density
• Increased lean body mass
• Post-surgical wound healing
• Body repair and recovery
• Better Sleep Quality

Introduction to CJC-1295

Formula: C152H252N44O42

Structure:Tyr-D-Ala-Asp-Ala-lle-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-lle-Leu-Ser-Arg

CJC-1295, Growth Hormone Releasing Hormone (GHRH), is a synthetic secretalogue which stimulates HGH release. In the body, large amounts of growth hormone are stored in the pituitary. GHRH affects the number of secreting cells and the amount they are able to secrete. 

Usage

CJC-1295 assists in muscle growth, fat loss and sleep improvement. This peptide can also increase energy in adults, quicken metabolism and aid in anti-aging benefits.

CJC-1295 and Ipamorelin are often taken together in order to maximize the amount of growth being released into your body. Ipamorelin, while having a similar effect as CJC- 1295, only works in the body for a short term (only a few hours), while CJC-1295 takes a little while to work, but will stay in the body for over a week. The combination CJC-1295/Ipamorelin provides a steady release of natural human growth hormone production in the pituitary over time and delivers more effective results for most people compared to CJC-1295 alone. 

Mechanism of Action

CJC-1295 prompts the secretion of human growth hormone (HGH) in the body through the pituitary gland. 

HGH is necessary for many systems in the body and regulates much more than just growth.  After around age 30, the amount of HGH in the body starts to decrease and sometimes very rapidly. This decrease of HGH is an innate process and mostly responsible for lower energy and muscle mass, increased inability to build new muscle, increased trouble losing or maintaining weight, weakened immune system, decreased healing efficiency and increased signs of aging.

Administration

Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area.

Before administering CJC-1295/Ipamorelin always be sure to use a clean and sterile syringe.

1. Hold the vial upright and insert the syringe in the center of the cap.
2. Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
3. Before administering the syringe, use alcohol to cleanse the area of skin.
4. Pinch the skin around the area to be injected, leave about 2 cm on each side.
5. Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
6. Depress the plunger fully, until the syringe is empty, and carefully draw out.

CJC-1295 take approximately 1-4 hours to reach peak serum levels, while Ipamorelin works quickly and is typically cleared out of the system rapidly as its half life is only about two hours.

Doses should be taken on an empty stomach, over one hour before and after eating.

Side Effects

CJC-1295 is known to have very subtle, if any side effects on most patients. Typically, most patients do not experience any side effects at all. However, some side effects that may occur are: sensitivity and pain at the injection site, headache, nausea, flu-like symptoms, dizziness, drowsiness, flushing of the skin, hyperactivity, difficulty swallowing and hives or rashes.

Benefits

• Increase of bone density, which can help prevent injuries
• Improvement of cardiovascular system strength
• Increase of muscle mass and higher metabolism
• Improved ability to burn fat
• Enhanced sex drive, improving mood and overall health
• Improved recovery time and healing of injuries
• Strengthening of the immune system

Improvement of memory function and cognition