Overview
Melanotan II (MT2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed to increase melanin production and provide a protective tan. By reducing the need for UV exposure, it may help lower the risk of skin cancer. MT2 is particularly beneficial for fair skin types prone to sunburn, and beyond tanning, it has demonstrated effects on appetite regulation, weight management, and sexual arousal.
Melanotan II (MT2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed to increase melanin production and provide a protective tan. By reducing the need for UV exposure, it may help lower the risk of skin cancer. MT2 is particularly beneficial for fair skin types prone to sunburn, and beyond tanning, it has demonstrated effects on appetite regulation, weight management, and sexual arousal.
Key Benefits of Melanotan II
- Tanning & UV Protection: Stimulates melanin for a deeper tan with less sun exposure, helping protect against UV damage and skin cancer.
- Skin Health: Extends tan duration, supports natural pigmentation, and reduces photoaging effects.
- Sexual Health: Increases libido and sexual arousal, with benefits for both men and women.
- Weight Management: Suppresses appetite, supports fat oxidation, and aids in lean mass preservation.
- Neuroprotection: Early research suggests potential benefits in Alzheimer’s, autism, and mood regulation.
Mechanism of Action
- MC-1R Stimulation: In melanocytes, promotes melanin production for enhanced pigmentation and photoprotection.
- MC-4R Stimulation: In the brain, influences sexual arousal, appetite suppression, and energy regulation.
Clinical Research and Applications
- Skin Cancer Prevention & Tanning: Increases pigmentation with minimal UV exposure, prolonging photoprotection.
- Sexual Function: Studied for erectile dysfunction and low sexual desire, with positive outcomes in both men and women.
- Weight & Appetite: Research shows reduced appetite and preference for high-fat foods via MC-4R pathways.
Side Effects and Considerations
- Short-term: Mild nausea, flushing, reduced appetite, spontaneous erections, darkening of moles/freckles.
- Long-term: Requires further study; some reports suggest risks of melanoma and pigmentation changes at high doses.
- Note: Use should be monitored due to regulatory concerns and potential risks.
Product Information
- Molecular Formula: C50H69N15O9
- Molecular Weight: 1024.198 g/mol
- Peptide Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Storage: Store frozen until first use; refrigerate at 2°C – 8°C for up to 56 days.
References
