Overview
KPV is a tripeptide fragment derived from α-melanocyte-stimulating hormone (α-MSH), composed of Lysine, Proline, and Valine. It exhibits strong anti-inflammatory and antimicrobial properties and has been studied as a therapeutic candidate for inflammatory and immune-mediated conditions, particularly in skin and gastrointestinal health.
KPV is a tripeptide fragment derived from α-melanocyte-stimulating hormone (α-MSH), composed of Lysine, Proline, and Valine. It exhibits strong anti-inflammatory and antimicrobial properties and has been studied as a therapeutic candidate for inflammatory and immune-mediated conditions, particularly in skin and gastrointestinal health.
Key Benefits of KPV
- Anti-Inflammatory Action: Works through the PepT1 transporter in the intestinal epithelium, making it valuable for conditions such as inflammatory bowel disease (IBD) and chronic ulcerative colitis.
- Antimicrobial Properties: Demonstrates antimicrobial activity, supporting skin health and reducing inflammation-related infections.
- Psoriasis Relief: Helps reduce itching, redness, and scaling associated with psoriasis, providing an alternative to long-term steroid treatments.
- Cancer and Inflammation Modulation: Early studies suggest potential anti-tumorigenic effects, particularly for colon cancer and other immune-driven conditions.
Mechanism of Action
KPV is absorbed via PepT1-mediated pathways in intestinal and immune cells, which are highly active in conditions such as colitis. Once inside the cytosol, KPV modulates inflammation by influencing cytokine production, NF-κB activity, and immune cell migration. Unlike α-MSH, it does not affect skin pigmentation, making it a safe therapeutic option without pigmentary side effects.
KPV is absorbed via PepT1-mediated pathways in intestinal and immune cells, which are highly active in conditions such as colitis. Once inside the cytosol, KPV modulates inflammation by influencing cytokine production, NF-κB activity, and immune cell migration. Unlike α-MSH, it does not affect skin pigmentation, making it a safe therapeutic option without pigmentary side effects.
Clinical Research
- Anti-Inflammatory Effects: Shown to reduce inflammation in animal models of dermatitis, IBD, fibrosis, and arthritis.
- Immune Modulation: Influences key inflammatory pathways, lowering cytokine activity and inflammatory cell infiltration.
- Steroid-Free Alternative: Provides therapeutic relief without the long-term risks of corticosteroids.
Product Information
- Product Name: KPV Peptide (Lysine-Proline-Valine)
- Applications:
- Anti-inflammatory support for immune-mediated conditions
- Potential therapy for IBD and ulcerative colitis
- Psoriasis symptom relief
- Research candidate for colon cancer and chronic inflammatory diseases
- Mode of Action: PepT1-mediated uptake for targeted anti-inflammatory and antimicrobial effects
- Compatibility: Suitable for long-term, non-steroidal therapeutic use
